Impatine
- Oncology Therapy
- Nephrology Therapy
- General Medicine
Impatine
IMPATINE tablets containing Capecitabine 500mg are Brown colored capsule shaped film coated tablets. Capecitabine is a fluoropyrimidine carbamate with antineoplastic activity. It is an orally administered systemic prodrug of 5′,-deoxy-5-fluoro- uridine (5’DFUR) which is converted to 5-fluorouracil.
Pharmacokinetics
In Colorectal Tumors and Adjacent Healthy Tissue
Following oral administration of Capecitabine 7 days before surgery in patients with colorectal cancer, the median ratio of 5 – FU concentration in colorectal tumors to adjacent tissues was 2.9 (range from 0.9 to 8.0 ). these ratios have not been evaluated in breast cancer patients or compared to 5-FU infusion.
- Dosage
- As directed by the Physician
- Uses
Capecitabine is indicated for the treatment of patients with metastatic breast cancer resistant to both paclitaxel and an anthracycline-containing chemotherapy regimen or resistant to paclitaxel and for whom further anthracycline therapy is not indicated.
- Warning
Altered coagulation parameters and/or bleeding have been reported in patients taking Capecitabine concomitantly with coumarin derivative anticoagulants such as warfarin and phenprocoumon.